Brett P. Monia (PhD) is a founding member of Ionis Pharmaceuticals (IONS) and the COO of the company. Dr. Monia was also the Franchise Leader for programs in Oncology and Rare Genetic Diseases at Ionis Pharmaceuticals. As head of Drug Discovery, Dr. Monia was responsible for establishing strategic directions for preclinical drug discovery research, establishing and supervising early clinical development strategies through clinical proof-of-concept, and coordinating research activities with clinical investigators, consultants, and corporate partners. Programs under Dr. Monia’s supervision have resulted in the clinical development of more than 25 antisense-based drugs to date across a broad range of therapeutic areas, including multiple marketing approvals. Dr. Monia’s publication record exceeds more than 200 research manuscripts, reviews, and book chapters, and he is the inventor of more than 100 issued patents. Dr. Monia received his Ph.D. in Pharmacology at the University of Pennsylvania and holds B.S. degrees in Molecular Biology and Analytical Chemistry. He serves on the editorial boards for numerous scientific journals, serves on the Board of Directors as Immediate Past President of the Oligonucleotide Therapeutics Society, and is an adjunct professor of biology at San Diego State University.